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To break it down a bit more, Mounjaro activates GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors, which are naturally occurring hormones found in ...
“Tirzepatide stimulates GLP-1 and GIP receptors, making it the first medication in its class to target both GIP and GLP-1 receptors.” The body naturally produces GIP and GLP-1, which Ngo ...
It works similarly to Ozempic, but also targets GIP receptors, in addition to GLP-1 receptors, Dr. Shah explains. Mounjaro notes on its website that up to 90% of patients taking the drug saw A1C ...
Tirzepatide has a greater affinity to GIP receptors than to GLP-1 receptors, and this dual agonist behavior has been shown to produce greater reductions of hyperglycemia compared to a selective GLP-1 receptor agonist. [14] Signaling studies reported that tirzepatide mimics the actions of natural GIP at the GIP receptor. [35]
The gastric inhibitory polypeptide receptor (GIP-R), also known as the glucose-dependent insulinotropic polypeptide receptor, is a protein that in humans is encoded by the GIPR gene. [ 5 ] [ 6 ] GIP-R is a member of the class B family of G protein coupled receptors . [ 7 ]
Tirzepatide (Mounjaro) is a potent GIP analog with agonist activity at GIP and GLP-1 receptors. It was approved for the treatment of type 2 diabetes in the United States in May 2022, and for the management of obesity in November 2023.
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