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Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.3.2) expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate (ATP) to create phosphocreatine (PCr) and adenosine diphosphate (ADP).
12715 Ensembl ENSG00000104879 ENSMUSG00000030399 UniProt P06732 P07310 RefSeq (mRNA) NM_001824 NM_007710 RefSeq (protein) NP_001815 NP_031736 Location (UCSC) Chr 19: 45.31 – 45.32 Mb Chr 7: 19.14 – 19.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Creatine kinase, muscle also known as MCK, CKMM, M-CK, and CPK-M, is a creatine kinase that in humans is encoded by the MCK gene ...
Creatine supplements are marketed in ethyl ester, gluconate, monohydrate, and nitrate forms. [40] Creatine supplementation for sporting performance enhancement is considered safe for short-term use but there is a lack of safety data for long term use, or for use in children and adolescents. [41] Some athletes choose to cycle on and off creatine ...
The presence of creatine kinase (CK-MB, creatine kinase myocardial band) in blood plasma is indicative of tissue damage and is used in the diagnosis of myocardial infarction. [ 1 ] The cell's ability to generate phosphocreatine from excess ATP during rest, as well as its use of phosphocreatine for quick regeneration of ATP during intense ...
Creatine kinase S-type, mitochondrial is an enzyme that in humans is encoded by the CKMT2 gene. [ 5 ] [ 6 ] Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine .
ATP + Creatine → H + + ADP + CP (Mg 2+ assisted, catalyzed by creatine kinase) ADP + P i → ATP (during anaerobic glycolysis and oxidative phosphorylation ) When the phosphagen system has been depleted of phosphocreatine (creatine phosphate), the resulting AMP produced from the adenylate kinase (myokinase) reaction is primarily regulated by ...
The majority of animals use arginine as phosphagen; however, the phylum Chordata (i.e., animals with spinal cords) use creatine. Creatine phosphate (CP), or phosphocreatine (PCr), is made from ATP by the enzyme creatine kinase in a reversible reaction: Creatine + ATP ⇌ creatine phosphate + ADP + H + (this reaction is Mg 2+-dependent)
12709 Ensembl ENSG00000166165 ENSMUSG00000001270 UniProt P12277 Q04447 RefSeq (mRNA) NM_001823 NM_001362531 NM_021273 RefSeq (protein) NP_001814 NP_001349460 NP_067248 Location (UCSC) Chr 14: 103.52 – 103.52 Mb Chr 12: 111.64 – 111.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse creatine kinase, ectopic expression Identifiers Symbol CKBE NCBI gene 1156 HGNC 1992 OMIM 123270 ...