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Currently, Kawasaki disease is the most commonly diagnosed pediatric vasculitis in the world. By far, the highest incidence of Kawasaki disease occurs in Japan, with the most recent study placing the attack rate at 218.6 per 100,000 children less than five years of age (about one in 450 children).
Kawasaki disease is most commonly seen in infants and children under five years old and is more likely to affect boys. The disease is self-limited which means that the inflammation will resolve after 6 to 8 weeks but if we left it untreated, there is a 20-25% risk of the heart complications we went over. Alright so let’s look at the symptoms ...
Kawasaki disease is a type of vasculitis where the endothelial cells in the coronary arteries become damaged, potentially leading to complications like myocardial infarction and aneurysms. This video covers the known pathophysiology, important signs and symptoms, diagnostic criteria, and treatment.
Acquired causes include atherosclerosis in adults, [4] Kawasaki disease in children [5] and coronary catheterization. With the invention of drug eluting stents, there has been more cases implying stents lead to coronary aneurysms. The pathophysiology, although not completely understood, might be comparable to that of aneurysms of larger vessels.
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In addition, MAS has been described in association with systemic lupus erythematosus (SLE), Kawasaki disease, and adult-onset Still's disease. It is thought to be closely related and pathophysiologically very similar to reactive (secondary) hemophagocytic lymphohistiocytosis (HLH). [1]
Kawasaki disease: Children with this disease also present with a strawberry tongue and undergo a desquamative process on their palms and soles. However, these children tend to be younger than five years old, their fever lasts longer (at least five days), and they have additional clinical criteria (including signs such as conjunctival redness ...
[5] [6] Beau's lines can also be seen one to two months after the onset of fever in children with Kawasaki disease. [7] Conditions also associated with Beau's lines include uncontrolled diabetes and peripheral vascular disease, as well as illnesses associated with a high fever, such as scarlet fever, measles, mumps and pneumonia.