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An autonomous thyroid nodule or "hot nodule" is one that has thyroid function independent of the homeostatic control of the HPT axis (hypothalamic–pituitary–thyroid axis). According to a 1993 article, such nodules need to be treated only if they become toxic ; surgical excision ( thyroidectomy ), radioiodine therapy , or both may be used.
Colloid nodules may be initially identified as an unspecified kind of thyroid nodule. Follow-up examinations typically include an ultrasound if it is unclear whether or not there really is a nodule present. Once the presence of a nodule has been confirmed, the determination of the kind of thyroid nodule is done by fine needle aspiration biopsy. [7]
Thyroid nodules are a major presentation of thyroid neoplasms, and are diagnosed by ultrasound guided fine needle aspiration (USG/FNA) or frequently by thyroidectomy (surgical removal and subsequent histological examination). FNA is the most cost-effective and accurate method of obtaining a biopsy sample. [5]
A nodule or lobe of the thyroid is sometimes removed for biopsy or because of the presence of an autonomously functioning adenoma causing hyperthyroidism. A large majority of the thyroid may be removed ( subtotal thyroidectomy) to treat the hyperthyroidism of Graves' disease , or to remove a goiter that is unsightly or impinges on vital structures.
Thyroid cancer affects tens of thousands of people per year, and the majority are women. Of the 44,000 people who will likely be diagnosed with thyroid cancer this year, more than 31,000 will be ...
The presence of ITNs in patients with another known malignancy is a common clinical problem with controversial management guidelines. Wilhelm et al. followed 41 patients with a known extra-thyroid malignancy and ITNs; 35 of them met the criterion for biopsy (nodule ≥ 1 cm).
A thyroid scan, performed often in conjunction with a radioactive iodine uptake test may be used to determine whether a nodule is hyperactive [27] which may help to make a decision whether to perform a biopsy of the nodule. [28] Measurement of calcitonin is necessary to exclude the presence of medullary thyroid cancer.
Papillary thyroid carcinoma is usually discovered on routine examination as an asymptomatic thyroid nodule that appears as a neck mass. In some instances, the mass may have produced local symptoms. This mass is normally referred to a fine needle aspiration biopsy (FNA) for investigation. FNA accuracy is very high and it is a process widely used ...