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Opsoclonus myoclonus syndrome (OMS), also known as opsoclonus-myoclonus-ataxia (OMA), is a rare neurological disorder of unknown cause which appears to be the result of an autoimmune process involving the nervous system. It is an extremely rare condition, affecting as few as 1 in 10,000,000 people per year.
Neuroblastoma (NB) is a type of cancer ... Horner's syndrome (cervical tumor, 2.4% of cases), opsoclonus myoclonus syndrome [10] and ataxia (suspected paraneoplastic ...
Opsoclonus consists of rapid, involuntary, multivectorial (horizontal and vertical), unpredictable, conjugate fast eye movements without inter-saccadic intervals. [1] It is also referred to as saccadomania or reflexive saccade. The movements of opsoclonus may have a very small amplitude, appearing as tiny deviations from primary position.
As with adults, anti-Hu encephalitis is associated with malignancy. The cancers most associated with anti-Hu encephalitis are neuroblastoma and ganglioneuroblastoma. Opsoclonus-myoclonus syndrome (OMS) is a condition that develops in children as a result of anti-Hu antibodies. The illness afflicts younger children, with one study showing an age ...
Symptomatic features of paraneoplastic syndrome cultivate in four ways: endocrine, neurological, mucocutaneous, and hematological.The most common presentation is a fever (release of endogenous pyrogens often related to lymphokines or tissue pyrogens), but the overall picture will often include several clinical cases observed which may specifically simulate more common benign conditions.
Kinsbourne was the first to identify and systematically describe the infant disorder "opsoclonus myoclonus" syndrome, sometimes called Kinsbourne syndrome in his honor. He also was first to describe "hiatus hernia" with contortions of the neck, subsequently called Sandifer Syndrome in honor of his mentor, Dr. Paul Sandifer.
Myoclonus can occur by itself, but most often as one of several symptoms associated with a variety of nervous system disorders, including multiple sclerosis, Parkinson's disease, Alzheimer's disease, opsoclonus myoclonus, Creutzfeldt–Jakob disease, Lyme disease and lupus.
This is a list of major and frequently observed neurological disorders (e.g., Alzheimer's disease), symptoms (e.g., back pain), signs (e.g., aphasia) and syndromes (e ...
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