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A cardiac stress test is a cardiological examination that evaluates the cardiovascular system's response to external stress within a controlled clinical setting. This stress response can be induced through physical exercise (usually a treadmill) or intravenous pharmacological stimulation of heart rate.
Owing to the mechanistic basis of PBPK models, another potential use of PBPK modeling is hypothesis testing. For example, if a drug compound showed lower-than-expected oral bioavailability, various model structures (i.e., hypotheses) and parameter values can be evaluated to determine which models and/or parameters provide the best fit to the ...
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Pharmacodynamics is sometimes abbreviated as PD and pharmacokinetics as PK, especially in combined reference (for example, when speaking of PK/PD models). Pharmacodynamics places particular emphasis on dose–response relationships , that is, the relationships between drug concentration and effect. [ 1 ]
Pharmacokinetics is based on mathematical modeling that places great emphasis on the relationship between drug plasma concentration and the time elapsed since the drug's administration. Pharmacokinetics is the study of how an organism affects the drug, whereas pharmacodynamics (PD) is the study of
The Harvard step test, in scientific literature sometimes referred to as the Brouha Test, is a type of cardiac stress test for detecting and diagnosing cardiovascular disease. It is also a good measurement of fitness and a person's ability to recover after a strenuous exercise by checking the recovery rate.
The Bruce protocol is a standardized diagnostic test used in the evaluation of cardiac function and physical fitness, developed by American cardiologist Robert A. Bruce. [1] According to the original Bruce protocol the patient walks on an uphill treadmill in a graded exercise test with electrodes on the chest to monitor.
Prime examples are flavonoids found in green tea, berries, cocoa, and spices as well as in the skins and seeds of apples, onions, and grapes. Investigations into healthful benefits of phytochemicals follow exactly the same principles of pharmacokinetics that are required to study drug therapy.