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Phentermine is an norepinephrine and dopamine releasing agent (NDRA) and produces stimulant, rewarding, and appetite suppressant effects. [8] [9] [10] Chemically, it is a substituted amphetamine. [11] Phentermine was approved for medical use in the United States in 1959. [3] It is available as a generic medication. [3]
Phentermine and topiramate can cause fetal harm. Data from pregnancy registries and epidemiology studies indicate that a fetus exposed to topiramate in the first trimester of pregnancy has an increased risk of oral clefts (cleft lip with or without cleft palate). [3]
Phentermine is a substituted amphetamine and topiramate has an unknown mechanism of action Approved for weight management (short-term) by the FDA but not the European Medicines Agency [ 54 ] 10% [ 55 ] or 8.25 kilograms (18.2 lb) [ 56 ]
Amphetamine, the prototypical monoamine releasing agent, which induces the release of dopamine and norepinephrine. [1]A monoamine releasing agent (MRA), or simply monoamine releaser, is a drug that induces the release of one or more monoamine neurotransmitters from the presynaptic neuron into the synapse, leading to an increase in the extracellular concentrations of the neurotransmitters and ...
Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4]
SSRIs have been used off-label in the treatment of stroke patients, including those with and without symptoms of depression. A 2021 meta-analysis of randomized controlled clinical trials found no evidence pointing to their routine use to promote recovery following stroke. [40]
Graphic representation of the Tax the Rich print from AOC's Met Gala dress Ocasio-Cortez attended the 2021 Met Gala , which had the theme "In America: a Lexicon of Fashion". The Met Gala is an annual fundraiser for the Metropolitan Museum of Art that is overseen by Vogue editor-in-chief Anna Wintour , who selects every invitee and designer pairing.
The 7.5 cm Infanteriegeschütz 37 (7.5 cm IG 37) was an infantry support gun, used by Germany during World War II.The guns were originally designated 7.5 cm PaK 37.The IG 37s were manufactured from carriages of 3.7 cm Pak 36s (and the nearly identical Soviet 3.7 cm PaK 158(r)) and a barrel designed originally for the IG 42 infantry support gun.