Search results
Results From The WOW.Com Content Network
The Sharpless epoxidation is viable with a large range of primary and secondary alkenic alcohols. Furthermore, with the exception noted above, a given dialkyl tartrate will preferentially add to the same face independent of the substitution on the alkene.To demonstrate the synthetic utility of the Sharpless epoxidation, the Sharpless group created synthetic intermediates of various natural ...
Asymmetric epoxidation is often feasible. [4] One named reaction is the Jacobsen epoxidation, which uses manganese-salen complex as a chiral catalyst and NaOCl as the oxidant. The Sharpless epoxidation using chiral N-heterocyclic ligands and osmium tetroxide. Instead of asymmetric epoxidation, alkenes are susceptible to asymmetric dihydroxylation.
Sharpless was a professor at the Massachusetts Institute of Technology (1970–1977, 1980–1990) and Stanford University (1977–1980). [8] While at Stanford, Sharpless discovered Sharpless asymmetric epoxidation, which was used to make (+)-disparlure. As of 2023, Sharpless led a laboratory at Scripps Research. [9]
Lithium, magnesium, and calcium [12] alkylperoxides have also been employed as asymmetric nucleophilic epoxidation reagents. Simple tartrate and pseudoephedrine ligands are effective in combination with these metals; however, little detailed information about the precise mechanisms of these systems is known.
It is often referred to as asymmetric amplification, a term coined by Oguni and co-workers. [4] An example of a positive non-linear effect is observed in the case of Sharpless epoxidation with the substrate geraniol.In all cases of chemical reactivity exhibiting (+)-NLE, there is an innate tradeoff between overall reaction rate and ...
Sharpless asymmetric dihydroxylation has also seen use as a method for kinetic resolution. [18] [19] This method is not widely used, however, since the same resolution can be accomplished in different manners that are more economical. Additionally, the Shi epoxidation has been shown to affect kinetic resolution of a limited selection of olefins ...
The epoxidation of allylic alcohols is a class of epoxidation reactions in organic chemistry. One implementation of this reaction is the Sharpless epoxidation . Early work showed that allylic alcohols give facial selectivity when using meta-chloroperoxybenzoic acid (m-CPBA) as an oxidant.
Enantioselective synthesis, also called asymmetric synthesis, [1] is a form of chemical synthesis. It is defined by IUPAC as "a chemical reaction (or reaction sequence) in which one or more new elements of chirality are formed in a substrate molecule and which produces the stereoisomeric ( enantiomeric or diastereomeric ) products in unequal ...