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Prazosin, sold under the brand name Minipress among others, is a medication used to treat high blood pressure, symptoms of an enlarged prostate, and nightmares related to post-traumatic stress disorder (PTSD). [6] It is an α 1 blocker. [6] It is a less preferred treatment of high blood pressure. [6] Other uses may include heart failure and ...
High doses of the α 1 blocker, prazosin, have been efficacious in treating patients with PTSD induced nightmares due to its ability to block the effects of norepinephrine. [27] Adverse effects of prazosin to treat PTSD nightmares include dizziness, first dose effect (a sudden loss of consciousness), weakness, nausea, and fatigue. [27]
The alpha blocker prazosin (Minipress) is most notorious for producing a first dose phenomenon. Other drugs of the same family, doxazosin (Cardura) and terazosin (Hytrin), can also cause this phenomenon, though less frequently. The cause is not clear.
Prazosin (Minipress) for nightmares: prazosin is approved for the use of hypertension. A 2012 systematic review showed a small benefit for the treatment of PTSD-associated night terrors. Other non-FDA-approved uses for prazosin include the treatment of Raynaud's disease and poisoning due to scorpion venom.
Specifically, scientists believe spicy foods are more likely to cause nightmares because they require more effort for the body to digest. They also elevate body temperature, which as stated before ...
Prazosin (alpha-1 blocker) appears useful in decreasing the number of nightmares and the distress caused by them in people with PTSD. [28] [29] Risperidone (atypical antipsychotic) at a dosage of 2 mg per day, has been shown in a case report to lead to the remission of nightmares on the first night. [29]
Prazosin is commonly used as an antihypertensive, but because alpha-1-adrenergic activity has been connected to fear and startle responses, it sees use as a PTSD treatment. [19] [20] Prazosin has been established as an effective and safe centrally active alpha-1-adrenergic receptor antagonist. It can be used to treat trauma-related nightmares ...
Prazosin would significantly decrease the number of PTSD related nightmares and would therefore improve sleep quality. [12] However, only few studies considered the effect of Prazosin in idiopathic nightmares. [12] Benzodiazepines are also often used to treat nightmare disorder, despite the lack of efficacy demonstrated in empirical studies. [12]