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Bladder instillation of medication is one of the main forms of treatment of interstitial cystitis, but evidence for its effectiveness is currently limited. [10] Advantages of this treatment approach include direct contact of the medication with the bladder and low systemic side effects due to poor absorption of the medication. [10]
A fistula involving the bladder can have one of many specific names, describing the specific location of its outlet: Bladder and intestine: "vesicoenteric", "enterovesical", or "vesicointestinal" [1] [2] [3] Bladder and colon: "vesicocolic" or "colovesical" [4] Bladder and rectum: "vesicorectal" or "rectovesical" [5]
Solabegron (code name GW-427,353) is a drug which acts as a selective agonist for the β 3 adrenergic receptor. It is being developed for the treatment of overactive bladder and irritable bowel syndrome. [1] [2] [3] It has been shown to produce visceral analgesia by releasing somatostatin from adipocytes. [4] [5]
Nearly 80% of patients discontinue use (mean of 4.8 months) of drugs within the first year [2] with as high as 17% of discontinuation being due to adverse side-effects. [3] Neuromodulation is emerging as an effective modality to treat patients who are not successful with conservative methods and its demonstrated efficacy has been the topic of ...
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.
Benefits appear similar to other medications in the class. [4] It is taken by mouth. [1] Common side effects include dry mouth, constipation, and urinary tract infection. [1] [2] Severe side effects may include urinary retention, QT prolongation, hallucinations, glaucoma, and anaphylaxis. [1] [3] [2] It is unclear if use is safe during ...