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Estroven is a dietary supplement, first produced in 1997, used to treat the effects of hormonal imbalance in women during all stages of menopause. Estroven contains a standardized extract of black cohosh ( Cimicifuga racemosa ) and plant-based estrogens (called isoflavones ) from soy , both used to help reduce hot flashes and night sweats .
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[5] [63] In terms of plasma protein binding, estrone is bound approximately 16% to sex hormone-binding globulin (SHBG) and 80% to albumin, [5] with the remainder (2.0 to 4.0%) circulating free or unbound. [7] Estrone has about 24% of the relative binding affinity of estradiol for SHBG, and hence is relatively poorly bound to SHBG. [5] [11]
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