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The cells of the brain include neurons and supportive glial cells. There are more than 86 billion neurons in the brain, and a more or less equal number of other cells. Brain activity is made possible by the interconnections of neurons and their release of neurotransmitters in response to nerve impulses.
Very large interconnected networks are called large scale brain networks, and many of these together form brains and nervous systems. Signals generated by neural networks in the brain eventually travel through the nervous system and across neuromuscular junctions to muscle cells, where they cause contraction and thereby motion. [2]
After the techniques of multielectrode recordings were introduced, the task of real-time decoding of information from large neuronal ensembles became feasible. If, as Georgopoulos showed, just a few primary motor neurons could accurately predict hand motion in two planes, reconstruction of the movement of an entire limb should be possible with enough simultaneous recordings.
Unipolar cells are exclusively sensory neurons. Their dendrites receive sensory information, sometimes directly from the stimulus itself. The cell bodies of unipolar neurons are always found in ganglia. Sensory reception is a peripheral function, so the cell body is in the periphery, though closer to the CNS in a ganglion.
Temporal averaging can work well in cases where the stimulus is constant or slowly varying and does not require a fast reaction of the organism — and this is the situation usually encountered in experimental protocols. Real-world input, however, is hardly stationary, but often changing on a fast time scale.
The general scientific community at the time was skeptical of Bain's [4] theory because it required what appeared to be an inordinate number of neural connections within the brain. It is now apparent that the brain is exceedingly complex and that the same brain “wiring” can handle multiple problems and inputs.
Each synapse in the circuit acts to delay the signal by about 0.5 msec, so that the more synapses there are, the longer is the delay to the output neuron. After the input has stopped, the output will go on firing for some time. This type of circuit does not have a feedback loop as does the reverberating circuit.
Functional integration is the study of how brain regions work together to process information and effect responses. Though functional integration frequently relies on anatomic knowledge of the connections between brain areas, the emphasis is on how large clusters of neurons – numbering in the thousands or millions – fire together under various stimuli.