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When taken orally, it achieves maximum concentration in about 6–10 hours [82] and reaches steady-state in 7–14 days. [93] Paroxetine exhibits significant interindividual variations in volume of distribution and clearance. [93] Less than 2% of an oral dose is excreted in urine unchanged. [93] Paroxetine is a mechanism-based inhibitor of ...
Of the 275, 93 were given paroxetine, 95 imipramine and 89 placebo. The paroxetine group were given 20 mg daily for four weeks, rising to 30 mg at week five and 40 mg at week six if the clinician thought it appropriate. [32] The last study visit was in May 1997, and the blind was broken in October. [33]
Occasionally symptoms can last up to one year. [3] They typically resolve within a day of restoring the medication. [20] Paroxetine and venlafaxine seem to be particularly difficult to discontinue, and prolonged withdrawal syndrome (post-acute-withdrawal syndrome, or PAWS) lasting over 18 months has been reported with paroxetine. [21] [22] [23]
Paroxetine (3S,4R)-3-[(2H-1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine [34] Paroxetine belongs to the phenylpiperidines. They contain a phenylpiperidine skeleton which consists of a piperidine bound to a phenyl group. [34] F The most potent 5-HT re-uptake blocker. It's the most potent blocker of muscarinic receptors among the SSRIs.
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.
Paroxetine may produce discontinuation-related symptoms at a greater rate than other SSRIs, though qualitatively similar effects have been reported for all SSRIs. [ 181 ] [ 182 ] Discontinuation effects appear to be less for fluoxetine, perhaps owing to its long half-life and the natural tapering effect associated with its slow clearance from ...