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Multiple probe designs may be useful in identifying extraneous factors which may be influencing your results. Lastly, experimenters should avoid gathering data during sessions alone. If in-session data is gathered a note of the dates should be tagged to each measurement in order to provide an accurate time-line for potential reviewers.
Multiplex ligation-dependent probe amplification (MLPA) is a variation of the multiplex polymerase chain reaction that permits amplification of multiple targets with only a single primer pair. [1] It detects copy number changes at the molecular level, and software programs are used for analysis.
In addition, with this design, bad probes affect all genotypes at a given locus equally. [3] For instance, since MIP probes can assay multiple genotypes at a particular genomic locus, if the probe for a given locus does not work (e.g. fails to properly hybridize to the genomic target), none of the genotypes at this locus will be detected.
In molecular biology, a hybridization probe (HP) is a fragment of DNA or RNA, usually 15–10000 nucleotides long, which can be radioactively or fluorescently labeled. HPs can be used to detect the presence of nucleotide sequences in analyzed RNA or DNA that are complementary to the sequence in the probe. [ 1 ]
Multiple baseline design involves simultaneous baseline measurement begins on two or more behaviours, settings, or participants. The IV is implemented on one behaviour, setting, or participant, while baseline continues for all others. Variations include the multiple probe design and delayed multiple baseline design. [1]
An AB design is a two-part or phase design composed of a baseline ("A" phase) with no changes and a treatment or intervention ("B") phase. [4] [5] If there is a change then the treatment may be said to have had an effect. However, it is subject to many possible competing hypotheses, making strong conclusions difficult.
Repeated measures design is a research design that involves multiple measures of the same variable taken on the same or matched subjects either under different conditions or over two or more time periods. [1] For instance, repeated measurements are collected in a longitudinal study in which change over time is assessed.
Scanning Hall probe microscope (SHPM) is a variety of a scanning probe microscope which incorporates accurate sample approach and positioning of the scanning tunnelling microscope with a semiconductor Hall sensor. Developed in 1996 by Oral, Bending and Henini, [2] SHPM allows mapping the magnetic induction associated with a sample.