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Isosorbide dinitrate is a medication used for heart failure, esophageal spasms, and to treat and prevent chest pain from not enough blood flow to the heart. [1] It has been found to be particularly useful in heart failure due to systolic dysfunction together with hydralazine. [2] [1] It is taken by mouth or under the tongue. [1]
Sacubitril/valsartan, sold under the brand name Entresto among others, is a fixed-dose combination medication for use in heart failure.It consists of the neprilysin inhibitor sacubitril and the angiotensin receptor blocker valsartan.
A new paper was published on these findings and MedCo filed for a new patent for the drug as a treatment for heart failure specifically in black patients. [ 4 ] [ 7 ] [ 8 ] The new patent and the old patent were then licensed to a company called NitroMed, which ran a clinical called the African-American Heart Failure Trial (A-HeFT), the results ...
Hydralazine is not used as a primary drug for treating hypertension because it elicits a reflex sympathetic stimulation of the heart (the baroreceptor reflex). [9] The sympathetic stimulation may increase heart rate and cardiac output , and in people with coronary artery disease may cause angina pectoris or myocardial infarction . [ 10 ]
Prolonged in congestive heart failure (mean 3.4 hrs) [45] [48] Prolonged in severe kidney failure (4 – 6 hrs) [49] and anephric patients (1.5 – 9 hrs) [46] Time to peak concentration (hrs) Intravenous administration 0.3 [50] Oral solution 0.83 [44] Oral tablet 1.45 [44] The pharmacokinetics of furosemide are not significantly altered by ...
Sleep apnea is an under-recognized risk factor for heart failure. Uncontrolled sleep apnea may increase the risk of heart failure by up to 140%. [4] Weight reduction – through physical activity and dietary modification, as obesity is a risk factor for heart failure and left ventricular hypertrophy. Effective weight management has been shown ...