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A nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune system due to a greatly reduced number of T cells. The phenotype (main outward appearance) of the mouse is a lack of body hair, which gives it the "nude" nickname.
BALB/c is an albino, laboratory-bred strain of the house mouse from which a number of common substrains are derived. Now over 200 generations from New York in 1920, BALB/c mice are distributed globally, and are among the most widely used inbred strains used in animal experimentation.
In 1973, Lauterbur published the first nuclear magnetic resonance image [1] [35] and the first cross-sectional image of a living mouse in January 1974. [36] In the late 1970s, Peter Mansfield , a physicist and professor at the University of Nottingham , England , developed the echo-planar imaging (EPI) technique that would lead to scans taking ...
MRI was originally called NMRI (nuclear magnetic resonance imaging), but "nuclear" was dropped to avoid negative associations. [2] Certain atomic nuclei are able to absorb radio frequency (RF) energy when placed in an external magnetic field ; the resultant evolving spin polarization can induce an RF signal in a radio frequency coil and thereby ...
NMRI may refer to: Nuclear magnetic resonance imaging; Naval Medical Research Institute, now part of the U.S. Navy's National Naval Medical Center
In spite of the efforts in developing this mouse model, poor engraftment of human hematopoietic stem cells (HSCs) was a major limitation that called for further advancement in the development humanized mouse models. [5] Nude mice were the earliest immunodeficient mouse model. These mice primarily produced IgM and had minimal or no IgA.
It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...
The linear transform model refers to a fundamental assumption guiding the analysis of functional Magnetic Resonance Imaging (fMRI) studies. Specifically, the model holds that the fMRI signal is approximately proportional to a measure of local neural activity, averaged over a spatial extent of several millimeters and over a time period of several seconds.