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Even in those who drink more than 120 g daily, only 13.5% will experience a serious alcohol-related liver injury. Nevertheless, alcohol-related mortality was the third leading cause of death in 2003 in the United States. Worldwide mortality is estimated to be 150,000 per year. [27] Alcoholic liver disease can lead to the development of exocrine ...
The basic trajectory of liquor in the body is from a person's mouth, through the esophagus, to the stomach, intestines, and the liver, where about 80-90% of the alcohol people consume is processed.
“Over time, this repeated damage can result in cirrhosis, where the liver becomes so scarred that it loses functionality,” she explains. This may eventually raise the risk of liver cancer. 2.
Alcohol is also directly damaging to liver cells. Alcohol is metabolized to acetaldehyde in the liver via the enzymes CYP2E1 and aldehyde dehydrogenase. [7] Acetaldehyde forms reactive oxygen species in the liver as well as acting as a DNA adduct (binding to DNA) leading to direct hepatocyte damage. [7]
For example, in the United States up to two million people have alcohol-related liver disorders. [151] Chronic heavy alcohol consumption can cause fatty liver, cirrhosis, and alcoholic hepatitis. Treatment options are limited and consist of most importantly discontinuing alcohol consumption.
With this in mind, both doctors say that the best way to do the least amount of damage to your liver (as well as the rest of the body) is to minimize alcohol consumption—if you choose to drink ...