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Chemokines (from Ancient Greek χῠμείᾱ (khumeíā) 'alchemy' and κῑ́νησῐς (kī́nēsis) 'movement'), or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells.
Chemokine receptors are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called a chemokine. [ 1 ] [ 2 ] There have been 20 distinct chemokine receptors discovered in humans. [ 3 ]
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1 (CCL2), a chemokine which specifically mediates monocyte chemotaxis.Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors.
Chemokine receptors, two of which act as binding proteins for HIV (CD4 and CCR5), also belong to this family. [citation needed] Interleukin-17 receptor (IL-17R) family, which shows little homology with any other cytokine receptor family. Structural motifs conserved between members of this family include: an extracellular fibronectin III-like ...
CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times.
2833 12766 Ensembl ENSG00000186810 ENSMUSG00000050232 UniProt P49682 O88410 RefSeq (mRNA) NM_001142797 NM_001504 NM_009910 RefSeq (protein) NP_001136269 NP_001495 NP_034040 Location (UCSC) Chr X: 71.62 – 71.62 Mb Chr X: 100.78 – 100.78 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Chemokine receptor CXCR3 is a Gα i protein-coupled receptor in the CXC chemokine receptor family ...
Cytokine receptors are receptors that bind to cytokines. [ 1 ] In recent years, the cytokine receptors have come to demand the attention of more investigators than cytokines themselves, partly because of their remarkable characteristics, and partly because a deficiency of cytokine receptors has now been directly linked to certain debilitating ...
CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 tightly regulates cellular mechanics [ 5 ] and thereby recruits monocytes , memory T cells , and dendritic cells to the sites of inflammation produced by either tissue injury or infection .