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The DNA repair function of alpha-synuclein appears to be compromised in Lewy body inclusion bearing neurons, and this may trigger cell death. Study of synucleinopathy mouse models of Parkinson's disease indicates that alpha-synuclein pathogenesis is associated with increased DNA damage and activation of the DNA damage response. [19]
Positive α-Synuclein staining of a Lewy body from a patient who had Parkinson's disease. Alpha synuclein, having no single, well-defined tertiary structure, is an intrinsically disordered protein, [77] [78] with a pI value of 4.7, [79] which, under certain pathological conditions, can misfold in a way that exposes its core hydrophobic residues ...
An anti-α-synuclein drug, or an α-synuclein inhibitor, is a drug which blocks or inhibits α-synuclein. [ 1 ] [ 2 ] α-Synuclein is a protein which is thought to be involved in the development and progression of α-synucleinopathies including Parkinson's disease , dementia with Lewy bodies , and multiple system atrophy .
Minzasolmin (development names DLX313 and UCB0599) is an experimental small-molecule drug developed for Parkinson's disease that is designed to prevent misfolding of α-synuclein. [ 1 ] [ 2 ] See also
Mutations in alpha-synuclein are associated with early-onset familial Parkinson's disease and the protein aggregates abnormally in Parkinson's disease, Lewy body disease, and other neurodegenerative diseases. [5] [6] The gamma-synuclein protein's expression in breast tumors is a marker for tumor progression. [7] [8]
Prasinezumab (INN Tooltip International Nonproprietary Name, USAN Tooltip United States Adopted Name; developmental code names NEOD002, PRX-002, RG-7935, RO-7046015) is an anti-α-synuclein drug acting as a monoclonal antibody against α-synuclein which is under development for the treatment of Parkinson's disease.
[10] [11] Genes which have been implicated in autosomal-dominant PD include PARK1 and PARK4, PARK5, PARK8, PARK11 and GIGYF2 and PARK13 which code for alpha-synuclein (SNCA), UCHL1, leucine-rich repeat kinase 2 (LRRK2 or dardarin) (LRRK2 and Htra2 respectively [9] [12] Genes such as PARK2, PARK6, PARK7 and PARK9 which code for parkin (PRKN ...
A brain tissue with Lewy bodies. The first major proposed cause of neuronal death in Parkinson's disease is the bundling, or oligomerization, of proteins.The protein alpha-synuclein has increased presence in the brains of Parkinson's Disease patients and, as α-synuclein is insoluble, it aggregates to form Lewy bodies (shown to left) in neurons.