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Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by a group of symptoms that commonly include abdominal pain, abdominal bloating and changes in the consistency of bowel movements. [1] These symptoms may occur over a long time, sometimes for years. [2]
Pentoxifylline, also known as oxpentifylline, is a xanthine derivative used as a drug to treat muscle pain in people with peripheral artery disease. [4] It is generic and sold under many brand names worldwide.
The effectiveness of this approach is unknown; a Cochrane review in 2016 found no published clinical trials including children. [89] Low levels of vitamin D are associated with crohn's disease and ulcerative colitis and people with more severe cases of inflammatory bowel disease often have lower vitamin D levels.
Pseudodiarrhea is often associated with rectal urgency and accompanies irritable bowel syndrome, hyperthyroidism, and anorectal disorders such as proctitis. Patients with rectal obstruction (e.g., from fecal impaction, obstruction due to a vaginal pessary) may also present with pseudodiarrhea, since only liquid stool can make it through. [2] [3]
The condition is usually caused by Gram-positive enteric commensal bacteria of the gut (). Clostridioides difficile is a species of Gram-positive bacteria that commonly causes severe diarrhea and other intestinal diseases when competing bacteria are wiped out by antibiotics, causing pseudomembranous colitis, whereas Clostridium septicum is responsible for most cases of neutropenic enterocolitis.
Such conditions include: Crohn's disease, infectious colitis, nonsteroidal anti-inflammatory drug enteropathy, and irritable bowel syndrome. Alternative causes of colitis should be considered, such as ischemic colitis (inadequate blood flow to the colon), radiation colitis (if prior exposure to radiation therapy ), or chemical colitis .