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Intravenous (IV) iron infusion is a therapy in which a combination of iron and saline solution is delivered directly into the bloodstream through a vein, in patients suffering iron deficiency, iron-deficiency anaemia and chronic kidney disease.
Whereas oral iron supplements could take upwards of six months to replenish someone’s iron levels, the results of IV iron are fairly instantaneous, says von Drygalski. If someone has heavy ...
[12] [13] There is low-certainty evidence that people receiving treatment for IBD-related anemia with Intravenous (IV) iron infusion may be 17% more likely to benefit than those given oral iron therapy, and could be 61% less likely to stop treatment early due to adverse effects. [14] However, the type of IV iron preparation may influence the ...
The various forms of treatment are not without possible adverse side effects. Iron supplementation by mouth commonly causes negative gastrointestinal effects, including constipation, nausea, vomiting, metallic taste to the oral iron and dark colored stools. [66] [41] Constipation is reported by 15–20% of patients taking oral iron therapy. [65]
Therefore, with frequent blood transfusions, iron builds up in the body over time. [2] This can enter the liver, heart, pancreas, and endocrine organs. [2] Free iron increases the production of oxygen radicals (mostly hydroxyl radicals) that cause damage to cells (particularly their DNA). [2]
Side effects include iron overloading, [12] [4] [9] [13] [5] allergic reactions that lead to skin rashes and infections transmitted through transfusion. [ 4 ] [ 12 ] The most common side effect is iron overloading, which the severity of overload depends on the frequency, volume, and the amount of blood transfused to the patient. [ 9 ]
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