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These LPC analogues are metabolically stable, and several ALPs such as edelfosine, miltefosine and perifosine are under research and development as drugs against cancer and other diseases. [ 6 ] [ 7 ] Lysophosphatidylcholine processing has been discovered to be an essential component of normal human brain development: those born with genes that ...
L-α-Glycerophosphorylcholine (alpha-GPC, choline alfoscerate, sn-glycero-3-phosphocholine) is a natural choline compound found in the brain. It is also a parasympathomimetic acetylcholine precursor [ 1 ] which has been investigated for its potential for the treatment of Alzheimer's disease [ 2 ] and other dementias .
General chemical structure of 1-lyso-phosphatidylcholines, where R is a variable fatty acyl group. 1-Lysophosphatidylcholines (or 1-lysoPC) are a class of phospholipids that are intermediates in the metabolism of lipids. They result from the hydrolysis of an acyl group from the sn-1 position of phosphatidylcholine.
1-Oleoyl-2-palmitoyl-phosphatidylcholine. Phosphatidylcholines (PC) are a class of phospholipids that incorporate choline as a headgroup.They are a major component of biological membranes and can easily be obtained from a variety of readily available sources, such as egg yolk or soybeans, from which they are mechanically or chemically extracted using hexane.
Critical periods are important for the development of the brain for the function from a pattern of connectivity. In general, the early auditory environment influences the structural development and response specificity of the primary auditory cortex.
Close regulation of its biosynthesis, degradation, and distribution is essential to proper cell function. Phosphatidylcholine is synthesized in vivo by two pathways The Kennedy pathway, which includes the transformation of choline to citicoline, by way of phosphorylcholine, produces phosphatidylcholine when condensed with diacylglycerol.
Phosphorylcholine (abbreviated ChoP) is the hydrophilic polar head group of some phospholipids, which is composed of a negatively charged phosphate bonded to a small, positively charged choline group.
Synaptic pruning, a phase in the development of the nervous system, is the process of synapse elimination that occurs between early childhood and the onset of puberty in many mammals, including humans. [1] Pruning starts near the time of birth and continues into the late-20s. [2]