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Microtubule and tubulin metrics [1]. Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells. Microtubules can be as long as 50 micrometres, as wide as 23 to 27 nm [2] and have an inner diameter between 11 and 15 nm. [3]
In cell biology, microtubule nucleation is the event that initiates de novo formation of microtubules (MTs). These filaments of the cytoskeleton typically form through polymerization of α- and β-tubulin dimers, the basic building blocks of the microtubule, which initially interact to nucleate a seed from which the filament elongates.
An array of microtubules can arrange themselves in a pinwheel structure to form the basal bodies, which can lead to the formation of microtubule arrays in the cytoplasm or the 9+2 axoneme. Other arrangements range from fungi spindle pole bodies to the eukaryotic chromosomal kinetochores (flat, laminated plaques).
Spindle microtubules emanate from centrosomes and 'seek' out kinetochores; when they bind a kinetochore they become stabilized and exert tension on the chromosomes. In an alternative self assembly model, microtubules undergo acentrosomal nucleation among the condensed chromosomes. Constrained by cellular dimensions, lateral associations with ...
Microtubules are assembled from dimers of α- and β-tubulin. These subunits are slightly acidic, with an isoelectric point between 5.2 and 5.8. [14] Each has a molecular weight of approximately 50 kDa. [15] To form microtubules, the dimers of α- and β-tubulin bind to GTP and assemble onto the (+) ends of microtubules while in the GTP-bound ...
At the negative ends of the aster centrosomes will nucleate (form a nucleus) and anchor to the microtubules. At the positive end, polymerization of the aster will occur. Cortical dynein, a motor protein, moves along the microtubules of the cell and plays a key role in the growth and inhibition of aster microtubules.
The building-block of the axoneme is the microtubule; each axoneme is composed of several microtubules aligned in a characteristic pattern known as the 9+2 axoneme as shown in the image at right. Nine sets of doublet microtubules (a specialized structure consisting of two linked microtubules) form a ring around a central pair of single ...
Since the centrosome organizes the microtubules of a cell, it has to do with the formation of the mitotic spindle, polarity and, therefore, cell shape, as well as all other processes having to do with the mitotic spindle. [2] The centriole is the inner core of the centrosome, and its conformation is typically somewhat like that of spokes on a ...