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[6] [5] [7] Ceftolozane is a cephalosporin antibiotic, developed for the treatment of infections with gram-negative bacteria that are resistant to conventional antibiotics. [8] It was studied for urinary tract infections, intra-abdominal infections and ventilator-associated bacterial pneumonia.
Cefuroxime axetil is a second generation cephalosporin that, like penicillins antibiotics, contains a β-lactam ring structure. Cephalosporins work as bactericidal antibiotics; that by binding to penicillin-binding proteins (PBPs) , inhibit the last step of the bacterial cell wall synthesis.
Cefotaxime is an antibiotic used to treat several bacterial infections in humans, other animals, and plant tissue culture. [3] Specifically in humans it is used to treat joint infections, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, sepsis, gonorrhea, and cellulitis. [3]
Cefazolin, also known as cefazoline and cephazolin, is a first-generation cephalosporin antibiotic used for the treatment of a number of bacterial infections. [2] Specifically it is used to treat cellulitis, urinary tract infections, pneumonia, endocarditis, joint infection, and biliary tract infections. [2]
Ofloxacin is a quinolone antibiotic useful for the treatment of a number of bacterial infections. [1] When taken by mouth or injection into a vein, these include pneumonia, cellulitis, urinary tract infections, prostatitis, plague, and certain types of infectious diarrhea.
Moxifloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase , a type II topoisomerase , and topoisomerase IV, [ 44 ] enzymes necessary to separate bacterial DNA, thereby inhibiting cell replication.
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