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As a blood pressure medication, spironolactone is usually prescribed at a dose of 25 milligrams a day. For acne, the dosage is higher: it’s often started at 50 mg and then titrated up to 100 mg ...
Spironolactone is an acne treatment prescribed by dermatologists. Find out how spironolactone improves the appearance of hormonal acne, side effects, and more. Everything I Wish I Knew About ...
Spironolactone: Spironolactone is used to treat high blood pressure but is also prescribed off-label for treating acne in women. Spironolactone reduces the amount of androgen hormones in your body ...
The effectiveness of spironolactone in the treatment of both acne and hirsutism appears to be dose-dependent, with higher doses being more effective than lower doses. [ 85 ] [ 96 ] [ 97 ] However, higher doses also have greater side effects, such as menstrual irregularities .
[1] [37] [126] Spironolactone is an aldosterone antagonist and is a useful acne treatment due to its ability to additionally block the androgen receptor at higher doses. [ 37 ] [ 106 ] Alone or in combination with a birth control pill, spironolactone has shown a 33 to 85% reduction in acne lesions in women. [ 117 ]
Pharmacokinetics of 100 mg/day spironolactone and its metabolites Compound C max Tooltip Peak concentrations (day 1) C max Tooltip Peak concentrations (day 15) AUC Tooltip Area-under-the-curve concentrations (day 15) t 1/2 Tooltip Elimination half-life; Spironolactone: 72 ng/mL (173 nmol/L) 80 ng/mL (192 nmol/L) 231 ng•hour/mL (555 nmol ...
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In one study, the threshold dose by subcutaneous injection for endometrial transformation in rabbits was 0.003–0.01 mg for cyproterone acetate, 0.1–0.3 mg for drospirenone, 0.5 mg for progesterone, and 10–20 mg for spironolactone. [119]