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A long-term deficiency in vitamin D can lead to osteoporosis, a disease that causes bone density loss, which can increase the risk of fractures and broken bones. Osteoporosis itself can also cause ...
Low activated vitamin D 3 levels are a result of the damaged kidneys' inability to convert vitamin D 3 into its active form, calcitriol, and result in further hypocalcemia. High levels of fibroblast growth factor 23 seem to be the most important cause of decreased calcitriol levels in CKD patients. [citation needed]
PTH acts on the kidneys to increase calcium reabsorption into the blood, and to inhibit phosphorus reabsorption (which causes phosphorus to be lost in the urine). [5] It increases calcium and phosphorus absorption in the bowel indirectly by stimulating the kidneys to produce vitamin D which then acts on the gut. [5]
The kidney fails to respond adequately to PTH, which normally promotes phosphaturia and calcium reabsorption, or to FGF-23, which also enhances phosphate excretion. [2] In addition, there is evidence at the tissue level of a downregulation of vitamin D receptor and of resistance to the actions of PTH.
These inactive forms of vitamin D get stored in fat cells until they are converted by the liver and kidneys into the active form of vitamin D. ... D deficiency, which can cause bone pain, muscle ...
Mapping of several bone diseases onto levels of vitamin D (calcidiol) in the blood [6] Normal bone vs. osteoporosis. Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body.