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Hypogonadotropic hypogonadism (HH), is due to problems with either the hypothalamus or pituitary gland affecting the hypothalamic-pituitary-gonadal axis (HPG axis). [1] Hypothalamic disorders result from a deficiency in the release of gonadotropic releasing hormone ( GnRH ), while pituitary gland disorders are due to a deficiency in the release ...
As women with FHA work to correct energy balance, especially female athletes and those recovering from eating disorder, recovery from hypogonadotropic hypogonadism may occur in a series of phases; there can be stages where the luteal phase is inadequate or may display lower sex steroid and gonadotropin levels for many years. [9]
The negative feedback control allows just the right amount of hormone to be released according to the needs of the body at that time. The structure of GNRH1 (from . The underlying cause of Kallmann syndrome or other forms of hypogonadotropic hypogonadism is a failure in the correct action of the hypothalamic hormone GnRH.
Hypogonadism resulting from defects of the gonads is referred to as hypergonadotropic hypogonadism or primary hypogonadism. Examples include Klinefelter syndrome and Turner syndrome . Mumps is known to cause testicular failure, and in recent years has been immunized against in the US.
Isolated hypogonadotropic hypogonadism (IHH), also called idiopathic or congenital hypogonadotropic hypogonadism (CHH), as well as isolated or congenital gonadotropin-releasing hormone deficiency (IGD), is a condition which results in a small subset of cases of hypogonadotropic hypogonadism (HH) due to deficiency in or insensitivity to gonadotropin-releasing hormone (GnRH) where the function ...
A eunuchoid body shape where the arm span exceeds the height by more than 5 cm suggests a delay in growth plate closure secondary to hypogonadism. [7] Turner syndrome has unique diagnostic features including a webbed neck, short stature, shield chest, and low hairline. [4] Klinefelter syndrome presents with tall stature as well as small, firm ...
Diagnosis of anovulation cause involves hormone level tests, in conjunction with an assessment of associated symptoms. A patient history and physical exam should include history of onset and pattern of oligomenorrhea or amenorrhea , signs of PCOS such as hyperandrogenism and obesity , eating disorders, causes of excessive physical or mental ...
46,XX gonadal dysgenesis is characteristic of female hypogonadism with a karyotype of 46,XX. [8] Streak ovaries are present with non-functional tissues unable to produce the required sex steroid oestrogen. [9] Low levels of oestrogen effect the HPG axis with no feedback to the anterior pituitary to inhibit the secretion of FSH and LH. [9]
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