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The Tet-On Advanced transactivator (also known as rtTA2 S-M2) is an alternative version of Tet-On that shows reduced basal expression, and functions at a 10-fold lower Dox concentration than Tet-Off. In addition, its expression is considered to be more stable in eukaryotic cells due to being human codon optimized and utilizing three minimal ...
Tet Repressor proteins (otherwise known as TetR) are proteins playing an important role in conferring antibiotic resistance to large categories of bacterial species. Tetracycline (Tc) is a broad family of antibiotics to which bacteria have evolved resistance. Tc normally kills bacteria by binding to the bacterial ribosome and halting protein ...
The Fredkin gate, [1] conceptualized by Edward Fredkin and Tommaso Toffoli at the MIT Laboratory for Computer Science, was a pivotal advancement in the field of reversible computing and conservative logic. Developed within the framework of conservative logic, the gate is designed to align computing processes with fundamental physical principles ...
In the reverse reaction, histone deacetylase (HDAC) removes the acetyl group from the histone tails and binds it to coenzyme A to form acetyl-CoA. Some coactivators indirectly regulate gene expression by binding to an activator and inducing a conformational change that then allows the activator to bind to the DNA enhancer or promoter sequence.
As was first argued by Rolf Landauer while working at IBM, [7] in order for a computational process to be physically reversible, it must also be logically reversible. Landauer's principle is the observation that the oblivious erasure of n bits of known information must always incur a cost of nkT ln(2) in thermodynamic entropy.
3GL—third-generation programming language; 3GPP—3rd Generation Partnership Project – 3G comms; 3GPP2—3rd Generation Partnership Project 2; 3NF—third normal form; 386—Intel 80386 processor; 486—Intel 80486 processor; 4B5BLF—4-bit 5-bit local fiber; 4GL—fourth-generation programming language; 4NF—fourth normal form
A computer system used for this purpose is called a speech synthesizer, and can be implemented in software or hardware products. A text-to-speech (TTS) system converts normal language text into speech; other systems render symbolic linguistic representations like phonetic transcriptions into speech. [1] The reverse process is speech recognition.
One early calculating machine, built entirely from wood by Thomas Fowler in 1840, operated in balanced ternary. [4] [5] [3] The first modern, electronic ternary computer, Setun, was built in 1958 in the Soviet Union at the Moscow State University by Nikolay Brusentsov, [6] [7] and it had notable advantages over the binary computers that eventually replaced it, such as lower electricity ...