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Mifepristone is approved in only one sub-Saharan African country—South Africa, where it was approved in 2001. [148] It is also approved in one north African country—Tunisia, also in 2001. [149] Mifepristone was approved for use in India in 2002, where medication abortion is referred to as "medical termination of pregnancy".
For medical abortion up to 12 weeks' gestation, the recommended drug dosages are 200 milligrams of mifepristone by mouth, followed one to two days later by 800 micrograms of misoprostol inside the cheek, vaginally, or under the tongue. [18] The success rate of this drug combination is 96.6% through 10 weeks' pregnancy. [19]
Use in pregnancy may harm the baby. [2] Mercaptopurine is in the thiopurine and antimetabolite family of medications. [4] [3] Mercaptopurine was approved for medical use in the United States in 1953. [2] It is on the World Health Organization's List of Essential Medicines. [5]
Misoprostol is regularly used in some Canadian hospitals for labour induction for fetal deaths early in pregnancy, and for termination of pregnancy for fetal anomalies. A low dose is used initially, then doubled for the remaining doses until delivery. In the case of a previous Caesarian section, however, lower doses are used.
The pregnancy category of a medication is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. It does not include any risks conferred by pharmaceutical agents or their metabolites in breast milk. Every drug has specific information listed in its product literature.
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Use during pregnancy may harm the baby. [6] Like all statins, rosuvastatin works by inhibiting HMG-CoA reductase, an enzyme found in the liver that plays a role in producing cholesterol. [6] Rosuvastatin was patented in 1991 and approved for medical use in the United States in 2003. [6] [7] It is available as a generic medication. [6]
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