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Protease inhibitors can cause a syndrome of lipodystrophy, hyperlipidemia, diabetes mellitus type 2, and kidney stones. [14] This lipodystrophy is colloquially known as "Crix belly", after indinavir (Crixivan). [15]
The NS5B protein, which is an RNA-dependent RNA polymerase, catalyzes hepatitis C virus replication. [10] The hepatitis C virus can cause acute infection but most patients are asymptomatic upon exposure. About one-third of patients develop symptoms such as fatigue, arthralgia and jaundice.
HCV is a positive-sense single-stranded RNA virus that has been demonstrated to replicate in the hepatocytes of both humans and chimpanzees. A single HCV polyprotein is translated, and then cleaved by cellular and viral proteases into three structural proteins (core, E1, and E2) and seven nonstructural proteins (p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B).
Danoprevir is a clinical candidate based on its favorable potency profile against multiple HCV genotypes 1–6 and key mutants (GT1b, IC 50 = 0.2–0.4 nM; replicon GT1b, EC 50 = 1.6 nM). [4] Danoprevir has been evaluated in an open-label, single arm clinical trial in combination with ritonavir for treating COVID-19 [ 5 ] and favourably ...
Cure rates are 94% to 99% in people infected with hepatitis C virus (HCV) genotype 1. [9] Some evidence also supports use in HCV genotype 3 and 4. [9] It is taken daily by mouth for 8–24 weeks. [8] It is generally well tolerated. [10] Common side effects include muscle pains, headache, nausea, rash, and cough. [8]
Ombitasvir is an antiviral drug for the treatment of hepatitis C virus (HCV) infection by AbbVie.In the United States, it is approved by the Food and Drug Administration for use in combination with paritaprevir, ritonavir and dasabuvir in the product Viekira Pak for the treatment of HCV genotype 1, [1] [2] and with paritaprevir and ritonavir in the product Technivie for the treatment of HCV ...