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Salicylate toxicity also causes an uncoupling of oxidative phosphorylation and a decrease in citric acid cycle activity in the mitochondria. [9] This decrease in aerobic production of adenosine triphosphate (ATP) is accompanied by an increase in anaerobic production of ATP through glycolysis which leads to glycogen depletion and hypoglycemia. [ 9 ]
Salicylates are derivatives of salicylic acid that occur naturally in plants and serve as a natural immune hormone and preservative, protecting the plants against diseases, insects, fungi, and harmful bacteria. Salicylates can also be found in many medications, perfumes and preservatives. Both natural and synthetic salicylates can cause health ...
Salicylic acid is a phenolic phytohormone, and is found in plants with roles in plant growth and development, photosynthesis, transpiration, and ion uptake and transport. [53] Salicylic acid is involved in endogenous signaling, mediating plant defense against pathogens. [54]
Salicylic acid as a medication is used to help remove the outer layer of the skin. [1] As such it is used to treat warts, calluses, psoriasis, dandruff, acne, ringworm, and ichthyosis. [1] [2] Because of its effect on skin cells, salicylic acid is used in some shampoos to treat dandruff. [medical citation needed]
Salicin from meadowsweet was used in the synthesis of aspirin (acetylsalicylic acid), [6] in 1899 by scientists at Bayer. Salicin tastes bitter like quinine. [7] Salicin may cause an allergic skin reaction (skin sensitization; category 1). [3] Mild side effects are standard, with rare occurrences of nausea, vomiting, rash, dizziness and ...
Ionizing radiation may be used to treat other cancers, but this may, in some cases, induce a second form of cancer. [74] Radiation can cause cancer in most parts of the body, in all animals, and at any age, although radiation-induced solid tumors usually take 10–15 years, and can take up to 40 years, to become clinically manifest, and ...
Dinitrochlorobenzene (DNCB), like salicylic acid, is applied directly to the wart. Studies show this method is effective with a cure rate of 80%. [medical citation needed] But DNCB must be used much more cautiously than salicylic acid; the chemical is known to cause genetic mutations, so it must be administered
Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. [2] It was developed by Merck Sharp & Dohme in 1971, as MK647, after showing promise in a research project studying more potent chemical analogs of aspirin. [3]