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Eosinophilic gastroenteritis (EG or EGE), also known as eosinophilic enteritis, [1] is a rare and heterogeneous condition characterized by patchy or diffuse eosinophilic infiltration of gastrointestinal (GI) tissue, first described by Kaijser in 1937.
Lirentelimab (sold under the brand name AK002) is a humanized nonfucosylated monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 ().In a randomized clinical trial, lirentelimab was found to improve eosinophil counts and symptoms in individuals with eosinophilic gastritis and duodenitis. [2]
Gluten-sensitive enteropathy–associated conditions are comorbidities or complications of gluten-related gastrointestinal distress (that is, gluten-sensitive enteropathy or GSE). GSE has key symptoms typically restricted to the bowel and associated tissues; however, there are a wide variety of associated conditions.
Eosinophilic gastroenteritis, also known as eosinophilic enteropathy or eosinophilic enteritis [7] – a rare and heterogeneous condition where eosinophils build up in the gastrointestinal tract and blood vessels, leading to polyp formation, necrosis, inflammation and ulcers. [8]
Eosinophilic enteropathy; A condition in which eosinophils (a type of white blood cell) accumulate in the gastrointestinal tract and in the blood. Eosinophil build up in the gastrointestinal tract can result in polyp formation, tissue break down, inflammation, and ulcers. [3] Coeliac disease
Abdominal pain, diarrhea, nausea, and vomiting are a few examples of gastrointestinal symptoms. There may be colitis, enterocolitis, or eosinophilic gastritis; if eosinophilic infiltrates affect the intestinal wall's deeper layers, colitis may be linked to ascitis. [13]
Stomach diseases include gastritis, gastroparesis, Crohn's disease and various cancers. [1] The stomach is an important organ in the body. It plays a vital role in digestion of foods, releases various enzymes and also protects the lower intestine from harmful organisms. The stomach connects to the esophagus above and to the small intestine below.
Gastritis is the inflammation of the lining of the stomach. [1] It may occur as a short episode or may be of a long duration . [ 1 ] There may be no symptoms but, when symptoms are present, the most common is upper abdominal pain (see dyspepsia ). [ 1 ]