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Fipronil is a broad-spectrum insecticide that belongs to the phenylpyrazole insecticide class. [3] Fipronil disrupts the insect central nervous system by blocking the ligand-gated ion channel of the GABA A receptor ( IRAC group 2B) and glutamate-gated chloride (GluCl) channels .
A comparison of 3 insecticides (selamectin, fipronil, imidacloprid) showed that selamectin reduced larval cat fleas ≥93.5% after 24 h at doses of ≥0.3 μg. In contrast, at 24 h neither fipronil nor imidacloprid reached 90% reduction, even at the highest doses tested (0.5 μg for fipronil and 5.0 μg for imidacloprid).
The US Food and Drug Administration (FDA) approved it for flea treatment in dogs in May 2014, [17] and approved the combination fluralaner/moxidectin (Bravecto Plus) as a topical treatment for cats in November 2019.
Comparative efficacy of two fipronil spot-on formulations against experimental tick infestations (Ixodes ricinus) in dogs. Parasitol Res. 2010 Aug;107(3):735-9. doi: 10.1007/s00436-010-1930-y ...
Chemical structure of fipronil, a common phenylpyrazole insecticide. Phenylpyrazole insecticides are a class of chemically-related broad-spectrum insecticides. [1] The chemical structures of these insecticides are characterized by a central pyrazole ring with a phenyl group attached to one of the nitrogen atoms of the pyrazole.
A veterinarian's warning is an important public service announcement to all pet owners — especially people who have cats. Dr. Michele Forbes, DVM shared an update amid the news that the H5N1 ...