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Atypical ductal hyperplasia (ADH) is the term used for a benign lesion of the breast that indicates an increased risk of breast cancer. [1]The name of the entity is descriptive of the lesion; ADH is characterized by cellular proliferation (hyperplasia) within one or two breast ducts and (histomorphologic) architectural abnormalities, i.e. the cells are arranged in an abnormal or atypical way ...
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Atypical hyperplasia is a high-risk premalignant lesion of the breast. It is believed that atypical ductal hyperplasia (ADH) is a direct precursor for low-grade mammary ductal carcinoma , whereas atypical lobular hyperplasia (ALH) serves as a risk indicator.
Like the cells of atypical lobular hyperplasia and invasive lobular carcinoma, the abnormal cells of LCIS consist of small cells with oval or round nuclei and small nucleoli detached from each other. [12] Mucin-containing signet-ring cells are commonly seen. LCIS generally leaves the underlying architecture intact and recognisable as lobules.
Atypical ductal hyperplasia is associated with a 2.4-fold risk. [20] In contrast, a New England Journal of Medicine article [ 21 ] states that for women with a strong familial history of breast cancer, the risk of future breast cancer is roughly doubled, independent of histological status.
Hyperplasia of the breast – "Hyperplastic" lesions of the breast include usual ductal hyperplasia, a focal expansion of the number of cells in a terminal breast duct, and atypical ductal hyperplasia, in which a more abnormal pattern of growth is seen, and which is associated with an increased risk of developing breast cancer. [2]
Examples include atypical ductal hyperplasia, atypical lobular hyperplasia, and intraductal papillomas. References. External links. Benign ...
Usual ductal hyperplasia (UDH) is a benign lesion of the breast wherein cells look very similar to normal. It is a spectrum of changes that can range from minimal stratification of cells to proliferations that are just short of atypical ductal hyperplasia .