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These include computer molecular models of molecules as varied as RNA polymerase, an E. coli, bacterial DNA primase template suggesting very complex dynamics at the interfaces between the enzymes and the DNA template, and molecular models of the mutagenic, chemical interaction of potent carcinogen molecules with DNA.
The most prominent examples of RNA genes are transfer RNA (tRNA) and ribosomal RNA (rRNA), both of which are involved in the process of translation. However, since the late 1990s, many new RNA genes have been found, and thus RNA genes may play a much more significant role than previously thought.
An example of RNA secondary structure. This image includes several structural elements, including; single-stranded and double-stranded areas, bulges, internal loops and hairpin loops. Double-stranded RNA forms an A-type helical structure, unlike the common B-type conformation taken by double-stranded DNA molecules.
Frequently the primary structure encodes motifs that are of functional importance. Some examples of sequence motifs are: the C/D [12] and H/ACA boxes [13] of snoRNAs, Sm binding site found in spliceosomal RNAs such as U1, U2, U4, U5, U6, U12 and U3, the Shine-Dalgarno sequence, [14] the Kozak consensus sequence [15] and the RNA polymerase III ...
For example, the RNA component of the human telomerase contains a pseudoknot that is critical for its activity. [7] The hepatitis delta virus ribozyme is a well known example of a catalytic RNA with a pseudoknot in its active site. [10] [11] Though DNA can also form pseudoknots, they are generally not present in standard physiological conditions.
For example, RNA polymerase is the modern common name for what was formerly known as RNA nucleotidyltransferase, a kind of nucleotidyl transferase that transfers nucleotides to the 3’ end of a growing RNA strand. [27] In the EC system of classification, the accepted name for RNA polymerase is DNA-directed RNA polymerase. [28]
Both types of pentoses in DNA and RNA are in their β-furanose (closed five-membered ring) form and they define the identity of a nucleic acid. DNA is defined by containing 2'-deoxy-ribose nucleic acid while RNA is defined by containing ribose nucleic acid. [1] In some occasions, DNA and RNA may contain some minor bases.
Transcription preinitiation complex, represented by the central cluster of proteins, causes RNA polymerase to bind to target DNA site. The PIC is able to bind both the promoter sequence near the gene to be transcribed and an enhancer sequence in a different part of the genome, allowing enhancer sequences to regulate a gene distant from it.