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In medicine, tapering is the practice of gradually reducing the dosage of a medication to reduce or discontinue it. Generally, tapering is done is to avoid or minimize withdrawal symptoms that arise from neurobiological adaptation to the drug.
In a comparison study, a rapid taper using benzodiazepines was found to be superior to a phenobarbital rapid taper. [106] [107] Pregabalin may help reduce the severity of benzodiazepine withdrawal symptoms, [108] and reduce the risk of relapse. [109] Propranolol was not found to increase the discontinuation success rate. [86]
Pregabalin, sold under the brand name Lyrica among others, is an anticonvulsant, analgesic, and anxiolytic amino acid medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless legs syndrome, opioid withdrawal, and generalized anxiety disorder (GAD). [13] [17] [18] Pregabalin also has antiallodynic properties.
New research suggests that slowly tapering off GLP-1 drugs like Ozempic and Wegovy may help prevent rebound weight gain. Yoshiyoshi Hirokawa/Getty Images This article originally appeared on Healthline
The most commonly used strategy is to offer opioid drug users long-acting opioid drugs and slowly taper the dose of the drug. Methadone, buprenorphine-naloxone, and naltrexone are all commonly used medications for opioid use disorder. [19] A review of UK hospital policies found that local guidelines delayed access to substitute opioids.
However, food has been found to substantially delay the absorption of pregabalin and to significantly reduce peak levels without affecting the bioavailability of the drug; T max values for pregabalin of 0.6 hours in a fasted state and 3.2 hours in a fed state (5-fold difference), and the C max is reduced by 25–31% in a fed versus fasted state ...
Used off-label to treat insomnia; Sonata – a non-benzodiazepine hypnotic; Spravato – a rapid-acting antidepressant of the NMDA receptor antagonist class; enantiomer of ketamine; Stelazine (trifluoperazine) – an antipsychotic used in the treatment of psychotic disorders, anxiety, and nausea caused by chemotherapy [2]
A version of this story appeared in CNN’s What Matters newsletter. To get it in your inbox, sign up for free here.. They booed former President Donald Trump, the Republican presidential ...