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Pneumoviridae (from Greek pneumo-'lung' + -viridae 'virus', from Latin, 'poison, slimy liquid') [2] is a family of negative-strand RNA viruses in the order Mononegavirales. [1] [3] Humans, cattle, and rodents serve as natural hosts. [4] Respiratory tract infections are associated with member viruses such as human respiratory syncytial virus.
Human metapneumovirus (HMPV or hMPV) is a negative-sense single-stranded RNA virus of the family Pneumoviridae and is closely related to the avian metapneumovirus (AMPV) subgroup C. It was isolated for the first time in 2001 in the Netherlands by using the RAP-PCR (RNA arbitrarily primed PCR ) technique for the identification of unknown viruses ...
The genome organization and RNA synthesis of order Mononegavirales. A virus is a member of the order Mononegavirales if [2] [3]. its genome is a linear, typically (but not always) nonsegmented, single-stranded, non-infectious RNA of negative polarity; possesses inverse-complementary 3' and 5' termini; and is not covalently linked to a protein;
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RSV structure and genome organization. (a) ~150 nm RSV virion particle and (b) single-stranded negative-sense RNA genome consisting of 10 genes (NS1-NS2-N-P-M-SH-G-F-M2-L). RSV has a negative-sense, single-stranded RNA genome. [2] The genome is linear and approximately 15,000 nucleotides in length. [3] It has 10 genes encoding for 11 proteins.
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The genus Orthopneumovirus is included in the family Pneumoviridae. Orthopneumoviruses are found specifically in the members of the species Homo sapiens, Ovis aries, Capra aegagrus hircus, Bos primigenius, and the order Rodentia. [citation needed] The most common pneumoviruses are as follows: [citation needed]
M – the matrix protein assembles between the envelope and the nucleocapsid core, it organizes and maintains virion structure; F – the fusion protein projects from the envelope surface as a trimer, and mediates cell entry by inducing fusion between the viral envelope and the cell membrane by class I fusion. One of the defining ...