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Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene. [5] IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins. [6]
Interleukin 10 (IL-10) is a protein that inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T cells. In structure, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulphide bonds. [33]
The IL-10 family is a family of interleukins. In addition to IL-10, it includes IL-19, IL-20, IL-22, IL-24 and IL-26. [1] Some sources also include the interferons IL-28 and IL-29. [2] The IL-10 family are helical cytokines categorized based on their specific similarities and can be classified as class 2 cytokines. [3]
Interleukin-10 receptor (IL-10R) is a type II cytokine receptor.The receptor is tetrameric, composed of 2α [1] and 2β [2] subunits. The α subunit (encoded in the Il10ra gene) is expressed on haematopoietic cells (such as T, B, NK, mast, and dendritic cells) whilst the β subunit (encoded in the Il10rb gene) is expressed ubiquitously.
B10 cells are presumed to originate from B10 progenitor (B10pro) cells, which can mature into B10eff cells with lipopolysaccharide (LPS) stimulation or CD40 litigation. [1] [8] In mice, B10eff cells (derived from B10 cells) actively secrete IL-10, whereas competency for IL-10 expression in B10pro cells must be induced by ex vivo stimulation. [1]
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3587 16154 Ensembl ENSG00000110324 ENSMUSG00000032089 UniProt Q13651 Q61727 RefSeq (mRNA) NM_001558 NM_008348 NM_001324486 RefSeq (protein) NP_001549 NP_001311415 NP_032374 Location (UCSC) Chr 11: 117.99 – 118 Mb Chr 9: 45.17 – 45.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin-10 receptor subunit alpha is a subunit for the interleukin-10 receptor. IL10RA is its ...