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Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
There are five types of hereditary hemochromatosis: type 1, 2 (2A, 2B), 3, 4 [9] and 5, [10] all caused by mutated genes. Hereditary hemochromatosis type 1 is the most frequent, and uniquely related to the HFE gene. It is most common among those of Northern European ancestry, in particular those of Celtic descent. [11]
They publish WebMD the Magazine, a patient-directed publication distributed bimonthly free of charge to 85 percent of physician waiting rooms. [13] Medscape is a professional portal for physicians and has training materials, a drug database, and clinical information on 30 medical specialty areas and more than 30 physician discussion boards. [ 14 ]
Hemochromatosis type 4 is a hereditary iron overload disorder that affects ferroportin, an iron transport protein needed to export iron from cells into circulation. [1] Although the disease is rare, it is found throughout the world and affects people from various ethnic groups.
With 150 locations throughout the Cleveland metropolitan area, the University Hospitals health system encompasses hospitals, outpatient centers, and primary care clinics. University Hospitals Cleveland Medical Center is the main teaching hospital of Case Western Reserve University. [2] [3] It also has an affiliation with the Northeast Ohio ...
Richmond Heights city, Ohio – Racial and ethnic composition Note: the US Census treats Hispanic/Latino as an ethnic category. This table excludes Latinos from the racial categories and assigns them to a separate category. Hispanics/Latinos may be of any race. Race / Ethnicity (NH = Non-Hispanic) Pop 2000 [14] Pop 2010 [15] Pop 2020 [16 ...
Headquartered in downtown Cleveland, Ohio, Medical Mutual of Ohio operates in the historic Rose Building. The Rose Building was erected in 1900 and "its innovative steel-frame structure was one of the first in Cleveland." [6] Meant to house dentists' offices, the Rose Building had almost 100 dentist tenants by 1902. [citation needed]
Norwalk is a city in and the county seat of Huron County, Ohio, United States. [6] The population was 17,068 at the 2020 census.The city is the center of the Norwalk micropolitan area and part of the Cleveland–Akron–Canton combined statistical area.