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A 2016 clinical trial for non-small cell lung cancer failed to meet its primary endpoint for treatment in the first-line setting, but is FDA-approved in subsequent lines of therapy. [160] Pembrolizumab (Keytruda) is another PD1 inhibitor that was approved by the FDA in 2014. Pembrolizumab is approved to treat melanoma and lung cancer. [159]
Efti has three intended clinical settings: as adjuvant to cancer vaccines (in a low, effective dose of ~250 μg) as first-line 'chemo-immunotherapy,' that is, combined with standard chemotherapy (e.g. paclitaxel) in combination immunotherapy with PD-1 treatments (e.g. pembrolizumab) Eftilagimod alpha is in Phase II clinical testing.
These therapies have revolutionized cancer immunotherapy as they showed for the first time in many years of research in metastatic melanoma, which is considered one of the most immunogenic human cancers, an improvement in overall survival, with an increasing group of patients benefiting long-term from these treatments, although caution remains ...
The phase II clinical trial in melanoma was published in 2009 [20] and the phase III trial was published in 2013. [21] Talimogene laherparepvec was approved by the US Food and Drug Administration to treat melanoma in October 2015. It was the first approval of an oncolytic virus and the first approval of a gene therapy in the West. [11]
As of 2016, it is in clinical trials for colorectal cancer, melanoma, breast cancer, non-small-cell lung carcinoma, bladder cancer, renal cell carcinoma. [50] [51] [needs update] Promising results have been observed for melanoma and non-small-cell lung cancer, [52] and bladder cancer. [13]
They explored the underlying immunology of the response and played a role in evaluating the first such drug in clinical trials for the treatment of advanced melanoma. [18] This led the development of new criteria for evaluating responses of cancer patients to immunotherapy in clinical trials. [19]
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