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The male infertility crisis is an increase in male infertility since the mid-1970s. [91] The issue attracted media attention after a 2017 meta-analysis found that sperm counts in Western countries had declined by 52.4 percent between 1973 and 2011.
In many countries, testicular FNA cytology is preferable to surgical testis biopsy for the evaluation of male infertility. In addition to accurately demonstrating the presence or absence of mature sperm with tails, FNA provides tubular cells for cytologic analysis, also informative for the diagnosis of infertility.
The main cause of male infertility is low semen quality. In men who have the necessary reproductive organs to procreate, infertility can be caused by low sperm count due to endocrine problems, drugs, radiation, or infection. There may be testicular malformations, hormone imbalance, or blockage of the man's duct system.
"The most common thing that causes infertility in men is a condition that's called varicose veins in the scrotum," Goldstein says. That was the issue for Joshua Kaiser of Texas.
The use of SCSA expands from evaluation of male infertility and subfertility, toxicology studies and evaluation of quality of laboratory semen samples. Notably, SCSA outcompetes other convention sperm DNA fragmentation (sDF) assays such as TUNEL and COMET in terms of efficiency, objectivity, and repeatability. Schematic representation of the SCSA.
The hamster zona-free ovum test was frequently performed by sperm banks when screening potential sperm donors.It was particularly useful in assessing the extent to which sperm from a potential donor could penetrate cervical mucus when artificial insemination was principally performed by ICI or IVI, rather than by IUI.