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The Diego antigen (or blood group) system is composed of 21 blood factors or antigens carried on the Band 3 glycoprotein, also known as Anion Exchanger 1 (AE1).The antigens are inherited through various alleles of the gene SLC4A1 (Solute carrier family 4), located on human chromosome 17.
Diego blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH; Band+3+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Chloride-Bicarbonate+Antiporters at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
The Di a antigen of the Diego antigen system has been found only in Indigenous peoples of the Americas and East Asians, and in people with some ancestry from those groups. The frequency of the Di a antigen in various groups of Indigenous peoples of the Americas ranges from almost 50% to 0%. [141]
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The term human blood group systems is defined by the International Society of Blood Transfusion (ISBT) as systems in the human species where cell-surface antigens—in particular, those on blood cells—are "controlled at a single gene locus or by two or more very closely linked homologous genes with little or no observable recombination between them", [1] and include the common ABO and Rh ...
Ii antigen system; Immunoglobulin therapy; Immunohaematology; Indian blood group system; International Society of Blood Transfusion; Intraoperative blood salvage; Intrauterine transfusion; Irish Blood Transfusion Service; ISBT 128
Blood compatibility testing is routinely performed before a blood transfusion.The full compatibility testing process involves ABO and RhD (Rh factor) typing; screening for antibodies against other blood group systems; and crossmatching, which involves testing the recipient's blood plasma against the donor's red blood cells as a final check for incompatibility.
The Er blood group system consists of five human red blood cell surface antigens, Er a, Er b, Er3, Er4 and Er5. [1] The incidences of Er a and Er3 are each greater than 99% of the human population, while the incidence of Er b is less than 0.01%. [2] [3] Er4 and Er5 are found at a high frequency in the general population. [1]