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Phenformin (DBI) was used from 1960s through 1980s, but was withdrawn due to lactic acidosis risk. [11] Buformin also was withdrawn due to lactic acidosis risk. [12] Metformin is a first-line medication used for treatment of type 2 diabetes.
Metformin-associated lactate production may also take place in the large intestine, which could potentially contribute to lactic acidosis in those with risk factors. [96] The clinical significance of this is unknown, though, and the risk of metformin-associated lactic acidosis is most commonly attributed to decreased hepatic uptake rather than ...
Lactic acidosis is commonly found in people who are unwell, such as those with severe heart and/or lung disease, a severe infection with sepsis, the systemic inflammatory response syndrome due to another cause, severe physical trauma, or severe depletion of body fluids. [3]
Metformin is a prescription medication used to treat high blood sugar in those with type 2 diabetes who are resistant to the effects of insulin. It’s in a class of drugs known as biguanides.
The medication most commonly may cause stomach upset and symptoms such as diarrhea but in general is well tolerated and has a relatively low chance of causing hypoglycemia. [35] One rare (about 1% chance) but serious side affect of metformin is that it can cause lactic acidosis, usually in patients with poor kidney function. [35]
It was marketed as DBI by Ciba-Geigy, but was withdrawn from most markets in the late 1970s due to a high risk of lactic acidosis, which was fatal in 50% of cases. Phenformin was developed in 1957 by Ungar, Freedman and Seymour Shapiro, working for the U.S. Vitamin Corporation. Clinical trials begun in 1958 showed it to be effective, but with ...