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Olopatadine is an active ingredient in eye drops designed to alleviate allergic conjunctivitis, a condition characterized by itchy, red, and watery eyes. It is intended to serve as a superior alternative to eye drops that contain corticosteroids. By utilizing olopatadine, the goal is to minimize the side effects associated with corticosteroids.
The most important factor that must be taken into account when designing any type of drug delivery device, and specifically ocular devices, is the release rate of a drug. As discussed previously, the deliver rate and kinetics associated with drugs to the eye can reach levels that are toxic to the eye or could even cause undesirable side effects.
The most common side effect is conjunctival hyperaemia (increased bloodflow in the outer layer of the eye), which occurs in over 10% of people taking the drug. Side effects in less than 10% of people include other eye problems such as itching, foreign body sensation or dry eye, as headache or hyperpigmentation (darkening) of the skin around the eye.
Serious side effects may include allergic reactions and heart failure. [3] Use is not recommended in those with asthma, a sulfonamide allergy, or a slow heart rate. [3] [7] Dorzolamide is a carbonic anhydrase inhibitor and timolol is a beta blocker. [3] Both work by decreasing the amount of aqueous humor made by the eye. [3]
Dry eye syndrome can lead to blurred vision, instability of the tear film, increased risk of damage to the ocular surface such as scarring of the cornea, and changes in the eye including the neurosensory system. [2] [6] Dry eye occurs when either the eye does not produce enough tears or when the tears evaporate too quickly. [2]
The most common side effects include conjunctival hyperaemia (red eye), pain at the site where the medicine was applied, cornea verticillata (deposits in the cornea, the transparent layer in front of the eye that covers the pupil and iris), pruritus (itching of the eye), erythema (reddening) and discomfort in the eye, increased lacrimation ...