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R74.8 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2025 edition of ICD-10-CM R74.8 became effective on October 1, 2024. This is the American ICD-10-CM version of R74.8 - other international versions of ICD-10 R74.8 may differ.
Alkaline phosphatase may be derived from several sites including the liver, bone, third trimester placenta, intestine, and kidneys. An elevation in alkaline phosphatase with a normal gamma-glutamyl transpeptidase or 5'-nucleotidase suggests a nonhepatic source of alkaline phosphatase.
Alkaline phosphatase (ALP) is an enzyme that exists throughout your body. High levels of ALP in your blood may indicate liver disease or certain bone disorders.
Elevated alkaline phosphatase occurs when levels of alkaline phosphatase (ALP) exceed the reference range. This group of enzymes has a low substrate specificity and catalyzes the hydrolysis of phosphate esters in a basic environment.
This article discusses the most common causes of raised alkaline phosphatase levels in an asymptomatic patient and provides advice on the relevant investigations.
Alkaline phosphatases (ALPs) are a group of isoenzymes located on the outer layer of the cell membrane. They catalyze the hydrolysis of organic phosphate esters found in the extracellular space. Zinc and magnesium are essential cofactors of this enzyme.
R74.8 is a billable diagnosis code used to specify a medical diagnosis of abnormal levels of other serum enzymes. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2024 through September 30, 2025.
Alkaline phosphatase (ALP) elevations tend to be more marked (more than 3-fold) in extrahepatic biliary obstructions (eg, by stone or cancer of the head of the pancreas) than in intrahepatic obstructions: the more complete the obstruction, the greater the elevation.
Elevated alkaline phosphatase describes the situation where the levels of alkaline phosphatase exceed the reference range. It can be associated with certain medical conditions or syndromes (e.g., hyperphosphatasia with mental retardation syndrome, HPMRS)
ICD-10 code R74.8 for Abnormal levels of other serum enzymes is a medical classification as listed by WHO under the range - Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified .