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Necrobiosis lipoidica is a rare, chronic skin condition predominantly associated with diabetes mellitus (known as necrobiosis lipoidica diabeticorum or NLD). [1] It can also occur in individuals with rheumatoid arthritis or without any underlying conditions ( idiopathic ). [ 2 ]
Necrobiosis is the physiological death of a cell, and can be caused by conditions such as basophilia, erythema, or a tumor. It is identified both with [ 1 ] and without necrosis . Necrobiotic disorders are characterized by presence of necrobiotic granuloma on histopathology.
Necrobiosis lipoidica; Limited joint mobility is observed in roughly 30% of people with diabetes with longstanding disease. [1] Scleredema; Waxy skin is observed in ...
Erythema nodosum (EN) is an inflammatory condition characterized by inflammation of subcutaneous fat tissue, resulting in painful red/blue lumps or nodules that are usually seen symmetrically on both shins, on the thighs, arms, and elsewhere. [1]
At the solar elastosis level, there is no necrobiosis, such as facial necrobiosis lipoidica, or mucinosis, such as GA or sarcoid-like granuloma in the dermis. [7] Because of the similarities in clinical manifestations, Actinic granuloma is easily confused with annular granuloma and sarcoidosis. In such cases, a histopathological examination is ...
Other conditions that should be taken into account in the differential diagnosis of granuloma multiforme include sarcoidosis, necrobiosis lipoidica diabeticorum, granuloma annulare, and the typical mimic of tuberculoid leprosy, [3] which has sensory impairment and thickening of the nerve trunk but no degenerated collagen. [6]
Other causes producing skin ulcers include bacterial and viral infections, fungal infections [6] and cancers. Blood disorders and chronic wounds can result in skin ulcers as well. [ 7 ] Venous leg ulcers due to impaired circulation or a blood flow disorder are more common in the elderly .
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