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The disease may also affect other parts of the body, including skin, eyes, lungs, heart, nerves, and blood. [1] This may result in a low red blood cell count, inflammation around the lungs, and inflammation around the heart. [1] Fever and low energy may also be present. [1] Often, symptoms come on gradually over weeks to months. [2]
Uveitis is described anatomically, by the part of the eye affected, as anterior, intermediate or posterior, or panuveitic if all parts are involved. Anterior uveitis ( iridocyclitis ) is the most common, with the incidence of uveitis overall affecting approximately 1:4500, most commonly those between the ages of 20–60.
Human eye. The ocular immune system protects the eye from infection and regulates healing processes following injuries. The interior of the eye lacks lymph vessels but is highly vascularized, and many immune cells reside in the uvea, including mostly macrophages, dendritic cells, and mast cells. [1]
An ocular manifestation of a systemic disease is an eye condition that directly or indirectly results from a disease process in another part of the body. There are many diseases known to cause ocular or visual changes.
Rheumatoid arthritis (RA) is a disorder in which the body's own immune system starts to attack body tissues specifically the cartilage at the end of bones known as articular cartilage. [74] The attack is not only directed at the joint but to many other parts of the body.
Eye disease: JIA is associated with inflammation in the front of the eye (specifically iridocyclitis, a form of chronic anterior uveitis), which affects about one in six children with JIA. Eye involvement occurs most commonly in girls, those with only a few joints involved ( oligoarthritis ), and those with a positive anti-nuclear antibody (ANA ...
Rheumatoid arthritis. Autoimmune diseases represent a vast and diverse category of disorders that, despite their differences, share some common symptomatic threads. [1] These shared symptoms occur as a result of the body's immune system mistakenly attacking its own cells and tissues, causing inflammation and damage.
Chloroquine retinopathy is a form of toxic retinopathy (damage of the retina) caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs. [3]
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