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Substances with a molar mass around 1000g/mol (e.g. thyroxine) are almost vertically aligned in the mass and molar images. Adrenocorticotropic hormone, on the other hand, with a molar mass of 4540, [ 13 ] is 0.7 decades to the right in the mass image.
Thyroid function tests (TFTs) is a collective term for blood tests used to check the function of the thyroid. [1] TFTs may be requested if a patient is thought to suffer from hyperthyroidism (overactive thyroid) or hypothyroidism (underactive thyroid), or to monitor the effectiveness of either thyroid-suppression or hormone replacement therapy.
Thyroxine, also known as T 4, is a hormone produced by the thyroid gland. It is the primary form of thyroid hormone found in the blood and acts as a prohormone of the more active thyroid hormone, triiodothyronine (T 3 ). [ 1 ]
Thyroxine (FT4) free 8-24 × 10 −12: total 4-12 × 10 −8: Thyroxine-binding prealbumin: 2.8-3.5 × 10 −4: Thyroxine-binding globulin: 1.0-3.4 × 10 −7: Tin: 0-4 × 10 −7: 0-1 × 10 −7: alpha-Tocopherol (Vitamin E) 5-20 × 10 −6: Transcortin: male 1.5-2 × 10 −5: female 1.6-2.5 × 10 −5: Transferrin: newborn 1.3-2.75 × 10 −3 ...
In overt primary hyperthyroidism, TSH levels are low and T 4 and T 3 levels are high. Subclinical hyperthyroidism is a milder form of hyperthyroidism characterized by low or undetectable serum TSH level, but with a normal serum free thyroxine level. [32]
Subclinical hypothyroidism is a biochemical diagnosis characterized by an elevated serum TSH level, but with a normal serum free thyroxine level. [48] [49] [50] The incidence of subclinical hypothyroidism is estimated to be 3-15% and a higher incidence is seen in elderly people, females and those with lower iodine levels. [48]