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The following other wikis use this file: Usage on ca.wikipedia.org Lisinopril; Usage on cy.wikipedia.org Lisinopril; Usage on el.wikipedia.org Λισινοπρίλη
The following other wikis use this file: Usage on ar.wikipedia.org ليزينوبريل; Usage on de.wikipedia.org Lisinopril; Usage on es.wikipedia.org
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Lisinopril leaves the body completely unchanged in the urine. [1] [16] The half-life of lisinopril is 12 hours, and is increased in people with kidney problems. [1] [16] While the plasma half-life of lisinopril has been estimated between 12 and 13 hours, the elimination half-life is much longer, at around 30 hours. [18]
Treatment should be mainly symptomatic and supportive, with volume expansion using normal saline to correct hypotension and improve renal function, and gastric lavage followed by activated charcoal and a cathartic to prevent further absorption of the drug. Captopril, enalapril, lisinopril and perindopril are known to be removable by hemodialysis.
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ADME is the four-letter abbreviation (acronym) for absorption, distribution, metabolism, and excretion, and is mainly used in fields such as pharmacokinetics and pharmacology. The four letter stands for descriptors quantifying how a given drug interacts within body over time.
Diagram illustrating renal flow along the nephron Main article: Excretion In pharmacology , the elimination or excretion of a drug is understood to be any one of a number of processes by which a drug is eliminated (that is, cleared and excreted ) from an organism either in an unaltered form (unbound molecules) or modified as a metabolite.