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A bone scan or bone scintigraphy / s ɪ n ˈ t ɪ ɡ r ə f i / is a nuclear medicine imaging technique used to help diagnose and assess different bone diseases. These include cancer of the bone or metastasis , location of bone inflammation and fractures (that may not be visible in traditional X-ray images ), and bone infection (osteomyelitis).
where, is a convolution operator, C bone (t) is the bone tissue activity concentration of tracer (in units: MBq/ml) over a period of time t, C plasma (t) is the plasma concentration of tracer (in units: MBq/ml) over a period of time t, IRF(t) is equal to the sum of exponentials, β values are fixed between 0.0001 sec −1 and 0.1 sec −1 in ...
For a bone scan, the patient is injected with a small amount of radioactive material, such as 700–1,100 MBq (19–30 mCi) of 99m Tc-medronic acid and then scanned with a gamma camera. Medronic acid is a phosphate derivative which can exchange places with bone phosphate in regions of active bone growth, so anchoring the radioisotope to that ...
Whole-body PET scan using 18 F-FDG (fluorodeoxyglucose). The normal brain and kidneys are labeled, and radioactive urine from breakdown of the FDG is seen in the bladder. In addition, a large metastatic tumor mass from colon cancer is seen in the liver. PET scanning with the radiotracer [18 F]fluorodeoxyglucose (FDG) is widely used in clinical ...
SPECT image (bone tracer) of a mouse MIP Collimator used to collimate gamma rays (red arrows) in a gamma camera. Single-photon emission computed tomography (SPECT, or less commonly, SPET) is a nuclear medicine tomographic imaging technique using gamma rays. [1]
PET radiotracer is a type of radioligand that is used for the diagnostic purposes via positron emission tomography imaging technique. [1] [2] Mechanism
A radioactive tracer, radiotracer, or radioactive label is a synthetic derivative of a natural compound in which one or more atoms have been replaced by a radionuclide (a radioactive atom). By virtue of its radioactive decay , it can be used to explore the mechanism of chemical reactions by tracing the path that the radioisotope follows from ...
It shows the concentration of a radiotracer within a region of interest in an image, measured over time from a dynamic scan. Generally, when a time-activity curve is obtained within a tissue, it is called as a tissue time-activity curve, which represents the concentration of tracer within a region of interest inside a tissue over time.